A non-invasive method for focusing ultrasound through the human skull

GT Clement, K Hynynen - Physics in medicine & biology, 2002 - iopscience.iop.org
A technique for focusing ultrasound through the human skull is described and verified. The
approach is based on a layered wavevector-frequency domain model, which propagates …

Correlation of ultrasound phase with physical skull properties

GT Clement, K Hynynen - Ultrasound in medicine & biology, 2002 - Elsevier
Noninvasive treatment of brain disorders using focused ultrasound (US) requires a reliable
model for predicting the distortion of the field due to the skull using physical parameters …

Trans-skull ultrasound therapy: The feasibility of using image-derived skull thickness information to correct the phase distortion

K Hynynen, J Sun - IEEE transactions on ultrasonics …, 1999 - ieeexplore.ieee.org
Recent papers have shown that focused ultrasound therapy may be feasible in the brain
through an intact human skull by using phased arrays to correct the phase distortion induced …

Focusing of therapeutic ultrasound through a human skull: a numerical study

J Sun, K Hynynen - The Journal of the Acoustical Society of America, 1998 - pubs.aip.org
A numerical model was developed which can use digitized layer interfaces to calculate
ultrasound wave absorption, diffraction, reflection, and refraction. This model was used to …

Transcranial ultrasound focus reconstruction with phase and amplitude correction

J White, GT Clement, K Hynynen - ieee transactions on …, 2005 - ieeexplore.ieee.org
Therapeutic and diagnostic ultrasound procedures performed noninvasively through the
skull require a reliable method for maintaining acoustic focus integrity after transmission …

A Magnetic Resonance Imaging–Compatible, Large‐Scale Array for Trans‐Skull Ultrasound Surgery and Therapy

GT Clement, PJ White, RL King… - Journal of ultrasound …, 2005 - Wiley Online Library
Objective Advances in ultrasound transducer array and amplifier technologies have
prompted many intriguing scientific proposals for ultrasound therapy. These include both …

Investigation of a large-area phased array for focused ultrasound surgery through the skull

GT Clement, J White, K Hynynen - Physics in Medicine & Biology, 2000 - iopscience.iop.org
Non-invasive treatment of brain disorders using ultrasound would require a transducer array
that can propagate ultrasound through the skull and still produce sufficient acoustic pressure …

A numerical study of transcranial focused ultrasound beam propagation at low frequency

X Yin, K Hynynen - Physics in Medicine & Biology, 2005 - iopscience.iop.org
The feasibility of transcranial ultrasound focusing with a non-moving phased array and
without skull-specific aberration correction was investigated using computer simulations …

Demonstration of potential noninvasive ultrasound brain therapy through an intact skull

K Hynynen, FA Jolesz - Ultrasound in medicine & biology, 1998 - Elsevier
Utilization of therapeutic ultrasound in the brain has been seriously limited by the commonly
accepted view that these exposures would require that a piece of the skull bone be removed …

A hemisphere array for non-invasive ultrasound brain therapy and surgery

GT Clement, J Sun, T Giesecke… - Physics in Medicine & …, 2000 - iopscience.iop.org
Ultrasound phased arrays may offer a method for non-invasive deep brain surgery through
the skull. In this study a hemispherical phased array system is developed to test the …