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Biochem J. 1992 Feb 15; 282(Pt 1): 231–235.
doi: 10.1042/bj2820231
PMCID: PMC1130912
PMID: 1371667

Glucose transporter expression and glucose utilization in skeletal muscle and brown adipose tissue during starvation and re-feeding.

D M Smith, S R Bloom, M C Sugden, and M J Holness
Author information Copyright and License information PMC Disclaimer

Abstract

Starvation (48 h) decreased the concentration of mRNA of the insulin-responsive glucose transporter isoform (GLUT 4) in interscapular brown adipose tissue (IBAT) (56%) and tibialis anterior (10%). Despite dramatic [7-fold (tibialis anterior) and 40-fold (IBAT)] increases in glucose utilization after 2 and 4 h of chow re-feeding, no significant changes in GLUT 4 mRNA concentration were observed in these tissues over this re-feeding period. The results exclude changes in GLUT 4 mRNA concentration in mediating the responses of glucose transport in these tissues to acute re-feeding after prolonged starvation.

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Selected References

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