Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase
- PMID: 17201629
- DOI: 10.1089/jmf.2006.9.451
Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase
Abstract
Epidemiological studies have shown that intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied. Reports have shown that green tea extract intake is associated with increased weight loss due to diet-induced thermogenesis, which is generally attributed to the catechin epigallocatechin gallate. That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis. Knowledge about thermogenesis-induced weight loss produced by green tea's epigallocatechin gallate and its ability to inhibit catechol-O-methyltransferase is important for health benefits and for prolonging the action of norepinephrine in the synaptic cleft.
Similar articles
-
Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity.Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8. doi: 10.1038/sj.ijo.0801101. Int J Obes Relat Metab Disord. 2000. PMID: 10702779
-
Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate.Drug Metab Dispos. 2003 May;31(5):572-9. doi: 10.1124/dmd.31.5.572. Drug Metab Dispos. 2003. PMID: 12695345
-
Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase.Drug Metab Dispos. 2004 May;32(5):497-504. doi: 10.1124/dmd.32.5.497. Drug Metab Dispos. 2004. PMID: 15100171
-
An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis).Planta Med. 2017 Apr;83(6):496-508. doi: 10.1055/s-0043-100934. Epub 2017 Jan 24. Planta Med. 2017. PMID: 28118673 Review.
-
Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise.Arthritis Res Ther. 2010;12(2):208. doi: 10.1186/ar2982. Epub 2010 Apr 28. Arthritis Res Ther. 2010. PMID: 20447316 Free PMC article. Review.
Cited by
-
A Comprehensive Review of the Effect of Honey on Human Health.Nutrients. 2023 Jul 6;15(13):3056. doi: 10.3390/nu15133056. Nutrients. 2023. PMID: 37447382 Free PMC article. Review.
-
Catechins: Protective mechanism of antioxidant stress in atherosclerosis.Front Pharmacol. 2023 Mar 24;14:1144878. doi: 10.3389/fphar.2023.1144878. eCollection 2023. Front Pharmacol. 2023. PMID: 37033663 Free PMC article. Review.
-
Nutraceuticals in Brown Adipose Tissue Activation.Cells. 2022 Dec 10;11(24):3996. doi: 10.3390/cells11243996. Cells. 2022. PMID: 36552762 Free PMC article. Review.
-
Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway.Pharmaceuticals (Basel). 2022 Apr 13;15(4):469. doi: 10.3390/ph15040469. Pharmaceuticals (Basel). 2022. PMID: 35455466 Free PMC article.
-
An Overview on How Exercise with Green Tea Consumption Can Prevent the Production of Reactive Oxygen Species and Improve Sports Performance.Int J Environ Res Public Health. 2021 Dec 25;19(1):218. doi: 10.3390/ijerph19010218. Int J Environ Res Public Health. 2021. PMID: 35010479 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
