Inhibition of carcinogenesis by tea constituents
- PMID: 17686632
- PMCID: PMC2736048
- DOI: 10.1016/j.semcancer.2007.06.013
Inhibition of carcinogenesis by tea constituents
Abstract
The possible cancer preventive activity of tea has received much attention in recent years. The inhibitory activities of tea and tea constituents against carcinogenesis at different organ sites have been demonstrated in many animal models. The effect of tea consumption on human cancers, however, remains inconclusive. The mechanisms of action of tea polyphenols, especially EGCG, the most abundant and active catechin, have been extensively investigated. Most of the studies, however, were based on cell culture systems, and these mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer. Human intervention trials are warranted to determine the possible prevention of cancer of specific sites by preparation of tea constituents.
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References
-
- Yang CS, Wang ZY. Tea and cancer. J Natl Cancer Inst. 1993;85:1038–49. - PubMed
-
- Mukhtar H, Katiyar SK, Agarwal R. Green tea and skin--anticarcinogenic effects. J Invest Dermatol. 1994;102:3–7. - PubMed
-
- Dreosti IE, Wargovich MJ, Yang CS. Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit Rev Food Sci Nutr. 1997;37:761–70. - PubMed
-
- Yang CS, Maliakal P, Meng X. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol. 2002;42:25–54. - PubMed
-
- Higdon JV, Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr. 2003;43:89–143. - PubMed
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