Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms
- PMID: 19585481
- DOI: 10.1002/ptr.2903
Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms
Erratum in
- Phytother Res. 2010 Apr;24(4):632
Abstract
The methanolic extract of fresh tea leaves of Camellia sinensis L. (Theaceae) (CS) was assayed for its potential to inhibit enzymes with hydrolytic activity in Naja naja kaouthia Lesson (Elapidae) and Calloselasma rhodostoma Kuhl (Viperidae) venoms. These snake venom enzymes are responsible for the early effects of envenomation, such as local tissue damage and inflammation. The CS extract inhibited phospholipase A(2), proteases, hyaluronidase and L-amino acid oxidase in both venoms by in vitro neutralization and inhibited the hemorrhagic and the dermonecrotic activities of the venoms in vivo. It is suggested that the inhibitory potential of the CS extract against local tissue damage induced by snake venoms may be attributed to complexation and chelation between the venom proteins and the phenolic contents of the extract.
Similar articles
-
Inhibition of key enzymes linked to snake venom induced local tissue damage by kolaviron.J Basic Clin Physiol Pharmacol. 2020 Dec 14;32(6):1121-1130. doi: 10.1515/jbcpp-2020-0176. J Basic Clin Physiol Pharmacol. 2020. PMID: 34898137
-
Anti-necrosis potential of polyphenols against snake venoms.Immunopharmacol Immunotoxicol. 2009;31(4):556-62. doi: 10.3109/08923970902821702. Immunopharmacol Immunotoxicol. 2009. PMID: 19874222
-
Molecular docking studies and anti-enzymatic activities of Thai mango seed kernel extract against snake venoms.Molecules. 2009 Mar 31;14(4):1404-22. doi: 10.3390/molecules14041404. Molecules. 2009. PMID: 19384272 Free PMC article.
-
Snake venom hyaluronidase: a therapeutic target.Cell Biochem Funct. 2006 Jan-Feb;24(1):7-12. doi: 10.1002/cbf.1261. Cell Biochem Funct. 2006. PMID: 16245359 Review.
-
[Action of venoms on blood coagulation: diagnosis of hemorrhagic syndromes].Bull Soc Pathol Exot. 2002 Aug;95(3):132-8. Bull Soc Pathol Exot. 2002. PMID: 12404853 Review. French.
Cited by
-
The Bioflavonoids Rutin and Rutin Succinate Neutralize the Toxins of B. jararaca Venom and Inhibit its Lethality.Front Pharmacol. 2022 Feb 21;13:828269. doi: 10.3389/fphar.2022.828269. eCollection 2022. Front Pharmacol. 2022. PMID: 35264963 Free PMC article.
-
Evaluation of Protection by Caffeic Acid, Chlorogenic Acid, Quercetin and Tannic Acid against the In Vitro Neurotoxicity and In Vivo Lethality of Crotalus durissus terrificus (South American Rattlesnake) Venom.Toxins (Basel). 2021 Nov 13;13(11):801. doi: 10.3390/toxins13110801. Toxins (Basel). 2021. PMID: 34822584 Free PMC article.
-
Green synthesis of silver nanoparticles using Indian male fern (Dryopteris Cochleata), operational parameters, characterization and bioactivity on Naja naja venom neutralization.Toxicol Res (Camb). 2020 Oct 15;9(5):706-713. doi: 10.1093/toxres/tfaa070. eCollection 2020 Sep. Toxicol Res (Camb). 2020. PMID: 33178431 Free PMC article.
-
Inhibition of Naja naja venom enzymes by the methanolic extract of Leucas aspera and its chemical profile by GC-MS.Toxicol Rep. 2014 Aug 29;1:667-673. doi: 10.1016/j.toxrep.2014.08.012. eCollection 2014. Toxicol Rep. 2014. PMID: 28962280 Free PMC article.
-
Ethnobotanical survey of folklore plants used in treatment of snakebite in Paschim Medinipur district, West Bengal.Asian Pac J Trop Biomed. 2014 May;4(5):416-20. doi: 10.12980/APJTB.4.2014C1120. Asian Pac J Trop Biomed. 2014. PMID: 25182729 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
