Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome
- PMID: 20605696
- PMCID: PMC2952043
- DOI: 10.1016/j.nut.2010.01.015
Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome
Abstract
Objective: Green tea (Camellia sinensis) has shown to exert cardioprotective benefits in observational studies. The objective of this clinical trial was to assess the effects of green tea on features of metabolic syndrome and inflammation in obese subjects.
Methods: We conducted a randomized controlled trial in obese subjects with metabolic syndrome. Thirty-five subjects [(mean ± SE) age 42.5 ± 1.7 y, body mass index 36.1 ± 1.3 kg/m(2)] completed the 8-wk study and were randomly assigned to receive green tea (4 cups/d), green tea extract (2 capsules and 4 cups water/d), or no treatment (4 cups water/d). Both the beverage and extract groups had similar dosing of epigallocatechin-3-gallate, the active green tea polyphenol. Fasting blood samples were collected at screening, 4 and 8 wk of the study.
Results: Green tea beverage or extract supplementation did not significantly alter features of metabolic syndrome or biomarkers of inflammation including adiponectin, C-reactive protein, interleukin-6, interleukin-1β, soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, leptin, or leptin:adiponectin ratio. However, both green tea beverage and extracts significantly reduced plasma serum amyloid alpha versus no treatment (P < 0.005).
Conclusion: This study suggests that the daily consumption of green tea beverage or extracts for 8 wk was well tolerated but did not affect the features of metabolic syndrome. However, green tea significantly reduced plasma serum amyloid alpha, an independent cardiovascular disease risk factor, in obese subjects with metabolic syndrome.
Copyright © 2011 Elsevier Inc. All rights reserved.
Conflict of interest statement
Similar articles
-
A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndrome.Nutr Res. 2024 Apr;124:94-110. doi: 10.1016/j.nutres.2024.02.001. Epub 2024 Feb 5. Nutr Res. 2024. PMID: 38430822 Clinical Trial.
-
Efficacy of tea catechin-rich beverages to reduce abdominal adiposity and metabolic syndrome risks in obese and overweight subjects: a pooled analysis of 6 human trials.Nutr Res. 2018 Jul;55:1-10. doi: 10.1016/j.nutres.2018.03.012. Epub 2018 Mar 23. Nutr Res. 2018. PMID: 29914623 Review.
-
Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults - a review.Obes Rev. 2016 Dec;17(12):1316-1328. doi: 10.1111/obr.12452. Epub 2016 Jul 22. Obes Rev. 2016. PMID: 27443447 Review.
-
Oral green tea catechins transiently lower plasma glucose concentrations in female db/db mice.J Med Food. 2013 Apr;16(4):312-7. doi: 10.1089/jmf.2012.0205. Epub 2013 Mar 20. J Med Food. 2013. PMID: 23514230
-
Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome.J Am Coll Nutr. 2010 Feb;29(1):31-40. doi: 10.1080/07315724.2010.10719814. J Am Coll Nutr. 2010. PMID: 20595643 Clinical Trial.
Cited by
-
The effect of green tea (Camellia sinensis) on lipid profiles and renal function in people with type 2 diabetes and nephropathy: a randomized controlled clinical trial.Front Nutr. 2023 Dec 14;10:1253275. doi: 10.3389/fnut.2023.1253275. eCollection 2023. Front Nutr. 2023. PMID: 38162524 Free PMC article.
-
Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases.Front Nutr. 2023 Jun 28;10:1202378. doi: 10.3389/fnut.2023.1202378. eCollection 2023. Front Nutr. 2023. PMID: 37448666 Free PMC article. Review.
-
The Preventive Mechanisms of Bioactive Food Compounds against Obesity-Induced Inflammation.Antioxidants (Basel). 2023 Jun 7;12(6):1232. doi: 10.3390/antiox12061232. Antioxidants (Basel). 2023. PMID: 37371961 Free PMC article. Review.
-
The effects of green tea supplementation on cardiovascular risk factors: A systematic review and meta-analysis.Front Nutr. 2023 Jan 10;9:1084455. doi: 10.3389/fnut.2022.1084455. eCollection 2022. Front Nutr. 2023. PMID: 36704803 Free PMC article. Review.
-
A 60-Day Green Tea Extract Supplementation Counteracts the Dysfunction of Adipose Tissue in Overweight Post-Menopausal and Class I Obese Women.Nutrients. 2022 Dec 7;14(24):5209. doi: 10.3390/nu14245209. Nutrients. 2022. PMID: 36558368 Free PMC article. Clinical Trial.
References
-
- Thielecke F, Boschmann M. The potential role of green tea catechins in the prevention of the metabolic syndrome - a review. Phytochemistry. 2009;70:11–24. - PubMed
-
- Wolfram S. Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr. 2007;26:373S–388S. - PubMed
-
- Crespy V, Williamson G. A review of the health effects of green tea catechins in in vivo animal models. J Nutr. 2004;134:3431S–3440S. - PubMed
-
- Rana JS, Nieuwdorp M, Jukema JW, Kastelein JJ. Cardiovascular metabolic syndrome – an interplay of, obesity, inflammation, diabetes and coronary heart disease. Diabetes Obes Metab. 2007;9:218–232. - PubMed
-
- Buscemi S, Verga S, Cottone S, Azzolina V, Buscemi B, Gioia D, Cerasola G. Glycaemic variability and inflammation in subjects with metabolic syndrome. Acta Diabetol. 2009;46:55–61. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials