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Randomized Controlled Trial
. 2018 May;74(5):601-609.
doi: 10.1007/s00228-018-2420-x. Epub 2018 Jan 24.

Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers

Shingen Misaka  1 , Osamu Abe  2   3 , Hideyuki Sato  4 , Tomoyuki Ono  2 , Yayoi Shikama  2   5 , Satomi Onoue  4 , Hirooki Yabe  3 , Junko Kimura  2
Affiliations
Randomized Controlled Trial

Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers

Shingen Misaka et al. Eur J Clin Pharmacol. 2018 May.

Abstract

Purpose: The objective of this study is to assess the effects of green tea and its major catechin component, (-)-epigallocatechin gallate (EGCG), on CYP2C9-mediated substrate metabolism in vitro, and the pharmacokinetics of fluvastatin in healthy volunteers.

Methods: The metabolism of diclofenac and fluvastatin in human recombinant CYP2C9 was investigated in the presence of EGCG. In a randomized three-phase crossover study, 11 healthy volunteers ingested a single 20-mg dose of fluvastatin with green tea extract (GTE), containing 150 mg of EGCG, along with water (300 mL), brewed green tea (300 mL), or water (300 mL) after overnight fasting. Plasma concentrations of fluvastatin and EGCG were measured by ultra-performance liquid chromatography with fluorescence detection and a single mass spectrometer.

Results: EGCG inhibited diclofenac 4'-hydroxylation and fluvastatin degradation with IC50 of 2.23 and 48.04 μM, respectively. Brewed green tea used in the clinical study also dose-dependently inhibited the metabolism of diclofenac and fluvastatin in vitro. However, no significant effects of GTE and brewed green tea were observed in plasma concentrations of fluvastatin. The geometric mean ratios with 90% CI for area under the plasma concentration-time curve (AUC0-∞) of fluvastatin were 0.993 (0.963-1.024, vs. brewed green tea) and 0.977 (0.935-1.020, vs. GTE).

Conclusions: Although in vitro studies indicated that EGCG and brewed green tea produce significant inhibitory effects on CYP2C9 activity, the concomitant administration of green tea and fluvastatin in healthy volunteers did not influence the pharmacokinetics of fluvastatin.

Keywords: (−)-Epigallocatechin gallate; CYP2C9; Diclofenac; Fluvastatin; Green tea; Pharmacokinetics.

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